Langerhans Cell-targeted Protein Delivery Enhances Antigen-Specific Cellular Immune Response
Targeted antigen delivery to immune cells, particularly dendritic cells, has emerged as a promising strategy to enhance therapeutic efficacy of vaccines, while minimizing adverse effects associated with conventional immunization. In this study, we use our previously described small glycomimetic molecule that selectively recognizes the Langerhans cell (LC)-specific surface receptor Langerin and demonstrate specific delivery of protein antigens to these specialized dendritic cells. Our results show that Langerin-mediated antigen delivery significantly enhances the immune response in vivo, resulting in increased expansion and activation of antigen-specific T cells, compared to immunization with unmodified antigen. We demonstrate the feasibility of our LC-targeted platform for immune cell-specific immunization with protein antigen and underscore the potential of LCs as an access point for next-generation vaccines and immunotherapies.
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Publication – ACS central science
A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting — Eike-Christian Wamhoff, Jessica Schulze, Lydia Bellmann, Mareike Rentzsch, Gunnar Bachem, Felix F. Fuchsberger, Juliane Rademacher, Martin Hermann, Barbara Del Frari, Rob van Dalen, David...
Publication – Biochemistry
A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing Cells — Jessica Schulze, Mareike Rentzsch, Donyoon Kim, Lydia Bellmann, Patrizia Stoitzner, Christoph Rademacher Biochemistry (2019), doi.org/10.1021/acs.biochem.9b0040
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